TIA1 antibody [N1N3]
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||43 kDa (note)
|Positive Controls||A549 , 293T , A431 , HeLa , HepG2 , Molt-4|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||TIA1 cytotoxic granule-associated RNA binding protein|
|Product Description||Rabbit Polyclonal antibody to TIA1 (TIA1 cytotoxic granule-associated RNA binding protein)|
|Background||The product encoded by this gene is a member of a RNA-binding protein family and possesses nucleolytic activity against cytotoxic lymphocyte (CTL) target cells. It has been suggested that this protein may be involved in the induction of apoptosis as it preferentially recognizes poly(A) homopolymers and induces DNA fragmentation in CTL targets. The major granule-associated species is a 15-kDa protein that is thought to be derived from the carboxyl terminus of the 40-kDa product by proteolytic processing. Alternative splicing resulting in different isoforms of this gene product has been described in the literature. [provided by RefSeq]|
|Synonyms||TIA-1 antibody, TIA1 antibody, T-cell-restricted intracellular antigen-1 antibody, nucleolysin TIA-1 isoform p40 antibody, p40-TIA-1 (containing p15-TIA-1) antibody, TIA1 cytotoxic granule-associated RNA binding protein antibody|
|Cellular Localization||Cytoplasmic granule|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TIA1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (90%), Zebrafish (83%), Xenopus laevis (88%), Chicken (89%), Rhesus Monkey (100%), Bovine (99%)|