|Full Name||TEK tyrosine kinase, endothelial|
|Product Description||Rabbit Polyclonal antibody to TIE2 (TEK tyrosine kinase, endothelial)|
|Background||The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [provided by RefSeq]|
|Synonyms||CD202B antibody, TIE-2 antibody, TIE2 antibody, VMCM antibody, VMCM1 antibody, TEK antibody, p140 TEK antibody, hTIE2 antibody, tyrosine-protein kinase receptor TIE-2 antibody, tyrosine-protein kinase receptor TEK antibody, soluble TIE2 variant 1 antibody, angiopoietin-1 receptor antibody, soluble TIE2 variant 2 antibody, tunica interna endothelial cell kinase antibody, "TEK tyrosine kinase, endothelial antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human TIE2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Bovine|
|Predict Reactivity Note||Rat (98%), Zebrafish (81%), Bovine (99%)|