TIGAR antibody [C2C3], C-term
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||30 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||chromosome 12 open reading frame 5|
|Product Description||Rabbit Polyclonal antibody to TIGAR (chromosome 12 open reading frame 5)|
|Background||This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq]|
|Synonyms||TIGAR antibody, C12orf5 antibody, TP53-induced glycolysis and apoptosis regulator antibody, "probable fructose-2,6-bisphosphatase TIGAR antibody", transactivated by NS3TP2 protein antibody, chromosome 12 open reading frame 5 antibody|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human TIGAR. The exact sequence is proprietary.|