|Full Name||chromosome 12 open reading frame 5|
|Product Description||Rabbit Polyclonal antibody to TIGAR (chromosome 12 open reading frame 5)|
|Background||This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq]|
|Synonyms||TIGAR antibody, C12orf5 antibody, TP53-induced glycolysis and apoptosis regulator antibody, "probable fructose-2,6-bisphosphatase TIGAR antibody", transactivated by NS3TP2 protein antibody, chromosome 12 open reading frame 5 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TIGAR. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (80%)|