| Full Name | TIMP metallopeptidase inhibitor 2 |
| Product Description | Mouse monoclonal antibody [3A4] to TIMP2 |
| Background | TIMP-1 and TIMP-2 are inhibitory enzymes of matrix metalloproteinase family. TIMPs are of great importance in the maintenance of connective tissue integrity. TIMP-2 shows the highest binding affinity to both the latent (pro) and active forms of 72 kD Type IV collagenase (MMP-2) and active form of 92 kD Type IV collagenase (MMP-9). TIMPs inhibit the proteolytic invasiveness of tumor cells and normal placental trophoblast cells. |
| Synonyms | CSC-21K Antibody |
| Cellular Localization | Cytoplasmic |
| Specificity | This antibody is specific for TIMP-2 (21 kDa). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | 3A4 |
| Target | TIMP2 |
| Isotype | IgG2a |
| Immunogen | BALB/C mice were injected with a synthetic peptide from the N-terminal region of human TIMP 2. |
| Light Chain | kappa |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse, Rat, Guinea pig, Rabbit, Bovine |