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1 .GTX20075 TIMP4 antibody

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TIMP4 antibody


  • Host / ClonalitySheep Polyclonal
  • ApplicationsDot, ELISA, ICC/IF, IHC, IP, WB
  • Species reactivityHuman
Cat No: GTX20075
Package Price Qty
100 μlUSD 239.00
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  • Anti-TIMP4 antibody used in Immunohistochemistry (IHC). GTX20075
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  • Datasheet
  • Application Information: TIMP4 antibody

Catalog Number GTX20075
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Product Name TIMP4 antibody
See all TIMP4 products
ApplicationsDot, ELISA, ICC/IF, IHC, IP, WB
Application NoteIHC: Use at an assay dependent dilution, IP: Use at an assay dependent dilution, WB: Use at an assay dependent dilution, Recognizes recombinant human TIMP-4 on WB. Optimal dilutions/concentrations should be determined by the end user.
Form SuppliedLiquid
Concentration10 mg/ml (Please refer to the vial label for the specific concentration)
PurificationTissue culture supernatant
Purification NoteThis reagent has been adsorbed to remove non-specific anti-human reactivity. The IgG fraction was obtained by protein A purification.

  • Specifications: TIMP4 antibody

Full NameTIMP metallopeptidase inhibitor 4
BackgroundThe tissue inhibitors of metalloproteinases (TIMPs) are naturally occurring proteins that specifically inhibit matrix metalloproteinases and regulate extracellular matrix turnover and tissue remodeling by forming tightbinding inhibitory complexes with the MMPs. Thus, TIMPs maintain the balance between matrix destruction and formation. An imbalance between MMPs and the associated TIMPs may play a significant role in the invasive phenotype of malignant tumors. The TIMP proteins share several structural features including six loops held in place by six disulfide bonds arranged in three knot-like structures. These proteins also contain twelve cysteine residues in conserved regions of the molecule that form six disulfide bonds, essential for the formation of native conformations, and the N terminal region that is necessary for inhibitory activities. The N terminus of each TIMP contains a consensus sequence (VIRAK) and each TIMP is translated with a 29 amino acid leader sequence that is cleaved off to produce the mature protein. The C terminal regions are divergent, which enhances the selectivity of inhibition and binding efficiency. Although the TIMP proteins share high homology, they may either be secreted extracellularly in soluble form (TIMP1, TIMP2 and TIMP4) or bind to extracellular matrix components (TIMP3). The MMPs and TIMPs can be divided into two groups with respect to gene expression: the majority exhibit inducible expression and a small number are produced constitutively or are expressed at very low levels and are not inducible. Among agents that induce MMP and TIMP production are the inflammatory cytokines TNF alpha and IL1 beta. A marked cell type specificity is a hallmark of both MMP and TIMP gene expression (i.e. a limited number of cell types can be induced to make these proteins). Tissue Inhibitor of Metalloproteinases 4 (TIMP4) was identified by molecular cloning. TIMP4 shows 37 % amino acid identity with TIMP1 and 51 % homology with TIMP2 and TIMP3. TIMP4 is secreted extracellularly, predominantly in heart and brain tissue. It may function in a tissue specific fashion in extracellular matrix (ECM) homeostasis. TIMP4 has a strong inhibitory effect on the invasion of human breast cancer cells across reconstituted basement membranes suggesting that TIMP4 may have an important role in inhibiting primary tumor growth and progression. The human TIMP4 gene has the chromosomal location of 3p25.
SynonymsTIMP metallopeptidase inhibitor 4 Tissue inhibitor of metalloproteinases 4 Metalloproteinase inhibitor 4 antibody TIMP 4 antibody TIMP metallopeptidase inhibitor 4 antibody Tissue Inhibitor of Metalloproteinase 4 antibody
HostSheep
ClonalityPolyclonal
ImmunogenKLH conjugate of a C-terminal peptide corresponding to aa 213-224 of human TIMP4
Antigen SpeciesHuman
Species ReactivityHuman
ConjugationUnconjugated

  • Storage Conditions: TIMP4 antibody

Storage BufferPhosphate-bufferd saline
Storage InstructionKeep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Disease Related > Cardiovascular > Vessels
  • Disease Related > Diabetes
  • Immunology > Autoimmunity > Autoimmune diseases > Diabetes
  • Immunology > Autoimmunity > Autoimmune diseases > Rheumatoid Arthritis
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TIMP4 antibody validated data
  • Anti-TIMP4 antibody used in Immunohistochemistry (IHC). GTX20075
    • GTX20075 IHC Image
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  • Anti-TIMP4 antibody used in Immunohistochemistry (IHC). GTX20075
    • GTX20075 IHC Image
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