|Full Name||tumor necrosis factor (ligand) superfamily, member 15|
|Product Description||Rabbit polyclonal antibody to TL1A (tumor necrosis factor (ligand) superfamily, member 15)|
|Background||The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. An additional isoform encoded by an alternatively spliced transcript variant has been reported but the sequence of this transcript has not been determined. [provided by RefSeq]|
|Synonyms||MGC129934 antibody, MGC129935 antibody, TL1 antibody, TL1A antibody, VEGI antibody, VEGI192A antibody, TNFSF15 antibody, vascular endothelial growth inhibitor-192A antibody, TNF superfamily ligand TL1A antibody, TNF ligand-related molecule 1 antibody, tumor necrosis factor ligand superfamily member 15 antibody, vascular endothelial cell growth inhibitor antibody, "tumor necrosis factor (ligand) superfamily, member 15 antibody"|
|Cellular Localization||Membrane; Single-pass type II membrane protein , Tumor necrosis factor ligand superfamily member 15 , secreted form: Secreted |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human TL1A. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Pig, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (100%), Pig (100%), Rhesus Monkey (100%), Chimpanzee (100%), Bovine (100%)|