|Full Name||transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)|
|Product Description||Rabbit Polyclonal antibody to TLE1 (transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila))|
|Background||Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG.|
|Synonyms||ESG antibody, ESG1 antibody, GRG1 antibody, TLE1 antibody, enhancer of split groucho-like protein 1 antibody, "transducin-like enhancer of split 1, homolog of Drosophila E(sp1) antibody", enhancer of split groucho 1 antibody, e(Sp1) homolog antibody, transducin-like enhancer protein 1 antibody, "transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human TLE1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (99%), Rat (99%), Rhesus Monkey (100%), Bovine (88%)|