|Full Name||toll-like receptor 3|
|Product Description||Rabbit Polyclonal antibody to TLR3 (toll-like receptor 3)|
|Background||The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta and pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate different length transcripts has been noted for this gene. [provided by RefSeq]|
|Synonyms||CD283 antibody, TLR3 antibody, toll-like receptor 3 antibody|
|Cellular Localization||Endoplasmic reticulum membrane; Single-pass type I membrane protein , Endosome membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TLR3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Cat, Pig, Rabbit, Sheep, Rhesus Monkey, Chimpanzee, Bovine, Guinea pig|
|Predict Reactivity Note||Mouse (81%), Rat (83%), Cat (86%), Pig (84%), Rabbit (82%), Sheep (87%), Rhesus Monkey (96%), Chimpanzee (98%), Bovine (86%), Guinea pig (84%)|