|Full Name||toll-like receptor 9|
|Product Description||Rabbit Polyclonal antibody to TLR9 (toll-like receptor 9)|
|Background||The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq]|
|Synonyms||CD289 antibody, TLR9 antibody, toll-like receptor 9 antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human TLR9. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Tupaia chinensis|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Cat, Pig, Sheep, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Dog (81%), Cat (85%), Pig (83%), Sheep (82%), Rhesus Monkey (95%), Chimpanzee (99%), Bovine (83%)|