Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||25 kDa (note)
|Positive Controls||293T , HepG2 , Neuro2A , CD830 , NIH-3T3 , Raw264.7 , C2C12 , PC-12 , Rat-2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||transmembrane emp24-like trafficking protein 10 (yeast)|
|Product Description||Rabbit Polyclonal antibody to TMP21 (transmembrane emp24-like trafficking protein 10 (yeast))|
|Background||This gene is a member of the EMP24/GP25L/p24 family and encodes a protein with a GOLD domain. This type I membrane protein is localized to the plasma membrane and golgi cisternae and is involved in vesicular protein trafficking. The protein is also a member of a heteromeric secretase complex and regulates the complex's gamma-secretase activity without affecting its epsilon-secretase activity. Mutations in this gene have been associated with early-onset familial Alzheimer's disease. This gene has a pseudogene on chromosome 8. [provided by RefSeq]|
|Synonyms||transmembrane emp24-like trafficking protein 10 (yeast) Antibody , p23 Antibody , P24(DELTA) Antibody , Tmp-21-I Antibody , S31III125 Antibody , S31I125 Antibody , TMED10 Antibody|
|Cellular Localization||Golgi apparatus membrane; Single-pass type I membrane protein; Lumenal side (By similarity) , Melanosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TMP21. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Rabbit, Chicken, Bovine|
|Predict Reactivity Note||Zebrafish (95%), Rabbit (99%), Chicken (96%), Bovine (100%)|