|Full Name||transmembrane protease, serine 2|
|Product Description||Rabbit polyclonal antibody to TMPRSS2 (transmembrane protease, serine 2)|
|Background||This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||FLJ41954 antibody, PP9284 antibody, PRSS10 antibody, TMPRSS2 antibody, serine protease 10 antibody, transmembrane protease serine 2 antibody, epitheliasin antibody, "transmembrane protease, serine 2 antibody"|
|Cellular Localization||Cell membrane; Single-pass type II membrane protein , Transmembrane protease , serine 2 catalytic chain: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TMPRSS2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (81%), Rat (80%), Bovine (81%)|