|Full Name||PYD and CARD domain containing|
|Product Description||Rabbit Polyclonal antibody to TMS1 (PYD and CARD domain containing)|
|Background||This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||ASC antibody, CARD5 antibody, MGC10332 antibody, TMS antibody, TMS-1 antibody, TMS1 antibody, PYCARD antibody, target of methylation-induced silencing 1 antibody, apoptosis-associated speck-like protein containing a CARD antibody, caspase recruitment domain-containing protein 5 antibody, PYD and CARD domain containing antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TMS1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rhesus Monkey (91%)|