| Background | Tumor Necrosis Factor (TNF) is a cytokine whose function is mediated through two distinct cell surface receptors (TNFR 1 and TNFR 2) that are included in the TNF receptor superfamily along with FAS antigen and CD40. Tumor necrosis factor receptor 1 and 2 (TNFR 1 and TNFR 2) are 55 and 75 kDa members of a family cell surface molecules including nerve growth factor receptor, Fas/Apo1, CD30, Ox40, and 4-1BB, which are characterized by cysteine rich motifs in the extracellular domain. |
| Synonyms | Tnfrsf1b, TNF receptor II, TNF-R-II, TNFR80, TNFR75, Tnfr2, 21938, TNF-R2, TNF-R75, p75, CD120b, TNFBR, Tnfr1, Tnfr-1, TNFRII, TNF R2, Tnfr 1, TNF R75, TNF R II |