TPP1 antibody [N1C1]
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||61 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||tripeptidyl peptidase I|
|Product Description||Rabbit Polyclonal antibody to TPP1 (tripeptidyl peptidase I)|
|Background||This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq]|
|Synonyms||CLN2 antibody, LPIC antibody, MGC21297 antibody, TPP1 antibody, lysosomal pepstatin insensitive protease antibody, tripeptidyl aminopeptidase antibody, growth-inhibiting protein 1 antibody, cell growth-inhibiting gene 1 protein antibody, tripeptidyl-peptidase 1 antibody, tripeptidyl peptidase I antibody|
|Cellular Localization||Lysosome , Melanosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TPP1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (86%), Dog (91%), Chimpanzee (100%), Bovine (91%)|