|Full Name||TNFRSF1A-associated via death domain|
|Product Description||Rabbit polyclonal antibody to TRADD (TNFRSF1A-associated via death domain)|
|Background||The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq]|
|Synonyms||Hs.89862 antibody, MGC11078 antibody, TRADD antibody, tumor necrosis factor receptor-1-associated protein antibody, tumor necrosis factor receptor type 1 associated death domain protein antibody, tumor necrosis factor receptor type 1-associated DEATH domain protein antibody, TNFR1-associated death domain protein antibody, TNFRSF1A-associated via death domain antibody|
|Cellular Localization||Cytoplasm , cytoskeleton |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TRADD. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Bovine (81%)|