|Full Name||TNF receptor-associated factor 2|
|Product Description||Goat polyclonal antibody to TRAF2|
|Background||Regulates activation of NF-kappa-B and JNK and plays a central role in the regulation of cell survival and apoptosis. Required for normal antibody isotype switching from IgM to IgG. Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-linked ubiquitination of target proteins, such as BIRC3, RIPK1 and TICAM1. Is an essential constituent of several E3 ubiquitin-protein ligase complexes, where it promotes the ubiquitination of target proteins by bringing them into contact with other E3 ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by inhibiting their autoubiquitination and subsequent degradation; this does not depend on the TRAF2 RING-type zinc finger domain. |
|Synonyms||TRAP, tumor necrosis factor type 2 receptor associated protein 3, TRAF2, TNF receptorassociated factor2, OTTHUMP00000064745, MGC:45012, TRAP3, TNF receptorassociated factor 2, tumor necrosis factor type2 receptor associated protein3, TNF receptor-associated factor 2|
|Specificity||This antibody is specific for TRAF2.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Bovine|