|Full Name||TNF receptor-associated factor 2|
|Product Description||Rabbit Polyclonal antibody to TRAF2 (TNF receptor-associated factor 2)|
|Background||The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from members of the TNF receptor superfamily. This protein directly interacts with TNF receptors, and forms a heterodimeric complex with TRAF1. This protein is required for TNF-alpha-mediated activation of MAPK8/JNK and NF-kappaB. The protein complex formed by this protein and TRAF1 interacts with the inhibitor-of-apoptosis proteins (IAPs), and functions as a mediator of the anti-apoptotic signals from TNF receptors. The interaction of this protein with TRADD, a TNF receptor associated apoptotic signal transducer, ensures the recruitment of IAPs for the direct inhibition of caspase activation. BIRC2/c-IAP1, an apoptosis inhibitor possessing ubiquitin ligase activity, can unbiquitinate and induce the degradation of this protein, and thus potentiate TNF-induced apoptosis. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of only one transcript has been determined. [provided by RefSeq]|
|Synonyms||MGC:45012 antibody, TRAP antibody, TRAP3 antibody, TRAF2 antibody, E3 ubiquitin-protein ligase TRAF2 antibody, tumor necrosis factor type 2 receptor associated protein 3 antibody, tumor necrosis factor type 2 receptor-associated protein 3 antibody, TNF receptor-associated factor 2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TRAF2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey|
|Predict Reactivity Note||Mouse (83%), Rat (84%), Rhesus Monkey (92%)|