|Full Name||TNF receptor-associated factor 3|
|Product Description||Rabbit polyclonal antibody to TRAF3 (TNF receptor-associated factor 3)|
|Background||The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins associate with, and mediate the signal transduction from, members of the TNF receptor (TNFR) superfamily. This protein participates in the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the lymphotoxin-beta receptor (LTbetaR) signaling complex, which induces NF-kappaB activation and cell death initiated by LTbeta ligation. Epstein-Barr virus encoded latent infection membrane protein-1 (LMP1) can interact with this and several other members of the TRAF family, which may be essential for the oncogenic effects of LMP1. Three alternatively spliced transcript variants encoding two distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||CAP-1 antibody, CD40bp antibody, CRAF1 antibody, LAP1 antibody, TRAF3 antibody, LMP1-associated protein 1 antibody, CD40 binding protein antibody, CD40 receptor associated factor 1 antibody, CD40 associated protein 1 antibody, TNF receptor-associated factor 3 antibody|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TRAF3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (96%), Rat (95%), Bovine (95%)|