|Full Name||tumor necrosis factor (ligand) superfamily, member 10|
|Product Description||Rabbit Polyclonal antibody to TRAIL (tumor necrosis factor (ligand) superfamily, member 10)|
|Background||The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. [provided by RefSeq]|
|Synonyms||APO2L antibody, Apo-2L antibody, CD253 antibody, TL2 antibody, TRAIL antibody, TNFSF10 antibody, tumor necrosis factor (ligand) family, member 10 antibody, tumor necrosis factor ligand superfamily member 10 antibody, tumor necrosis factor apoptosis-inducing ligand splice variant delta antibody, chemokine tumor necrosis factor ligand superfamily member 10 antibody, Apo-2 ligand antibody, TNF-related apoptosis inducing ligand TRAIL antibody, tumor necrosis factor (ligand) superfamily, member 10 antibody|
|Cellular Localization||Membrane; Single-pass type II membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TRAIL. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Cat, Pig, Rhesus Monkey, Chimpanzee|
|Predict Reactivity Note||Cat (81%), Pig (80%), Rhesus Monkey (97%), Chimpanzee (98%)|