|Full Name||tripartite motif containing 72|
|Product Description||Rabbit Polyclonal antibody to TRIM72 (tripartite motif-containing 72)|
|Background||Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch formation. Probably acts upstream of the Ca(2+)-dependent membrane resealing process. Required for transport of DYSF to sites of cell injury during repair patch formation. Regulates membrane budding and exocytosis. May be involved in the regulation of the mobility of KCNB1-containing endocytic vesicles.|
|Synonyms||MG53 antibody, TRIM72 antibody, mitsugumin-53 antibody, tripartite motif-containing protein 72 antibody, tripartite motif-containing 72 antibody, tripartite motif containing 72 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TRIM72. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rabbit|
|Predict Reactivity Note||Mouse (93%), Rat (94%), Rabbit (89%)|