|Full Name||COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis)|
|Product Description||Rabbit Polyclonal antibody to TRIP15 (COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis))|
|Background||Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.|
|Synonyms||ALIEN antibody, CSN2 antibody, SGN2 antibody, TRIP15 antibody, COPS2 antibody, thyroid receptor-interacting protein 15 antibody, thyroid receptor interacting protein 15 antibody, alien homolog antibody, COP9 signalosome complex subunit 2 antibody, TR-interacting protein 15 antibody, signalosome subunit 2 antibody, TRIP-15 antibody, JAB1-containing signalosome subunit 2 antibody, COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TRIP15. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Pig, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Zebrafish (98%), Xenopus laevis (99%), Pig (100%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)|