|Applications||ELISA, ICC/IF, IP, WB|
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||44 kDa (note)
|Positive Controls||U87-MG , SK-N-SH , IMR32 , SK-N-AS , 293T , A431 , HeLa , HepG2 , K562 , THP-1 , HL-60|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||tumor susceptibility gene 101|
|Product Description||Rabbit Polyclonal antibody to TSG101 (tumor susceptibility gene 101)|
|Background||The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq]|
|Synonyms||TSG10 antibody, VPS23 antibody, TSG101 antibody, ESCRT-I complex subunit TSG101 antibody, tumor susceptibility gene 101 protein antibody, tumor susceptibility protein antibody, tumor susceptibility gene 101 antibody|
|Cellular Localization||Cytoplasm , Membrane; Peripheral membrane protein , Nucleus , Late endosome membrane; Peripheral membrane protein |