|Full Name||tetratricopeptide repeat domain 8|
|Product Description||Goat polyclonal antibody to TTC8|
|Background||The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. |
|Synonyms||tetratricopeptide repeat domain 8, tetratricopeptide repeat domain8, BardetBiedl syndrome type8, TTC8, BBS8, BardetBiedl syndrome type 8, Bardet-Biedl syndrome type 8, RP51, Bardet Biedl syndrome type 8|
|Cellular Localization||Localizes to nonmembranous centriolar satellites in the cytoplasm. |
|Specificity||This antibody is specific for TTC8.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Dog, Bovine, Pig|