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Catalog Number
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GTX48126-PRO
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0
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Product Name
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Thrombomodulin Recombinant Protein (Active)
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| Full Name | thrombomodulin |
| Synonyms | BDCA3, BDCA-3, CD141, THBD, TM, BDCA 3 |
| Product Description | Active Recombinant Human Thrombomodulin protein |
| Background | Thrombomodulin (TM, CD141, THBD) is an endothelial cell expressed transmembrane glycoprotein that can form a complex with the coagulation factor, Thrombin. The Thrombomodulin/Thrombin complex converts protein C to its activated form, protein Ca, which in turn proteolytically cleaves and deactivates factor Va and factor VIIIa, two essential components of the coagulation mechanism. This inactivation reduces the generation of additional thrombin and thereby effectively prevents continued coagulation. Reduced levels of Thrombomodulin can correlate with the pathogenesis of certain cardiovascular diseases, such as atherosclerosis and thrombosis. However, the serum levels of the truncated circulating form of Thrombomodulin are typically elevated during inflammation and in the presence of various inflammatory related diseases. Recombinant soluble Thrombomodulin is a 491 amino acid glycoprotein containing the extracellular domain of Thrombomodulin. |
| Target | Thrombomodulin |
| Species | Human |
| Expression System | Human |
| Applications | ELISA, WB, Functional Assay |
| Application Note | Biological activity was measured by its ability to activate protein C induced cleavage of the chromogenic substrate, BOC-Asp-Pro Arg-AMC in the presence of thrombin. The specific activity is greater than 500 pmoles/min/ug. |
| Form Supplied | Lyophilized powder |
| Purification Note | Greater than or equal to 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg). |
| Purity | Greater than or equal to 98% by SDS-PAGE gel and HPLC analyses. Endotoxin level is less than 0.1 ng per µg (1EU/µg). |
| Storage Instruction | The lyophilized Thrombomodulin recombinant protein is stable for at least 2 years from date of receipt at -20ºC. Reconstituted Thrombomodulin is stable for at least 3 months when stored in working aliquots with a carrier protein at -20ºC. As with any prot |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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