|Full Name||thymidylate synthetase|
|Product Description||Rabbit polyclonal antibody to Thymidylate synthase|
|Background||Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase. [provided by RefSeq]|
|Synonyms||HST422 antibody, MGC88736 antibody, TMS antibody, TS antibody, TYMS antibody, TSase antibody, thymidylate synthase antibody, thymidylate synthetase antibody|
|Target||Thymidylate synthetase |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Thymidylate synthetase. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Dog, Pig, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (95%), Zebrafish (88%), Xenopus laevis (85%), Dog (96%), Pig (96%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (91%)|