Thyroid Hormone Receptor beta antibody [N1N3]
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||53 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)|
|Product Description||Rabbit polyclonal antibody to Thyroid Hormone Receptor beta (thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian))|
|Background||The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq]|
|Synonyms||ERBA-BETA antibody, ERBA2 antibody, GRTH antibody, MGC126109 antibody, MGC126110 antibody, NR1A2 antibody, PRTH antibody, THR1 antibody, THRB1 antibody, THRB2 antibody, THRB antibody, thyroid hormone receptor beta 1 antibody, oncogene ERBA2 antibody, "thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian) antibody", thyroid hormone receptor beta antibody, nuclear receptor subfamily 1 group A member 2 antibody, thyroid hormone nuclear receptor beta variant 1 antibody|
|Cellular Localization||Nucleus |
|Target||Thyroid Hormone Receptor beta|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Thyroid Hormone Receptor beta. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Sheep|
|Predict Reactivity Note||Mouse (93%), Rat (92%), Sheep (90%)|