Timeless antibody [N1N2], N-term
|Applications||ICC/IF, IHC-P, WB|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||139 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||timeless homolog (Drosophila)|
|Product Description||Rabbit Polyclonal antibody to Timeless (timeless homolog (Drosophila))|
|Background||Required for normal progression of S-phase. Involved in the circadian rhythm autoregulatory loop. Negatively regulates CLOCK-NPAS2/BMAL1-induced transactivation of PER1 possibly via translocation of PER1 into the nucleus. Promotes TIPIN nuclear localiZation. Involved in cell survival after DNA damage or replication stress. May be specifically required for the ATR-CHK1 pathway in the replication checkpoint induced by hydroxyurea or ultraviolet light. May also play an important role in epithelial cell morphogenesis and formation of branching tubules.|
|Synonyms||FLJ12640 antibody, FLJ20714 antibody, TIM antibody, TIM1 antibody, hTIM antibody, TIMELESS antibody, protein timeless homolog antibody, timeless homolog (Drosophila) antibody|
|Cellular Localization||Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human TIMELESS. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Sheep, Bovine|
|Predict Reactivity Note||Mouse (90%), Rat (90%), Sheep (93%), Bovine (93%)|