|Full Name||topoisomerase (DNA) I|
|Product Description||Rabbit Polyclonal antibody to Topo I (topoisomerase (DNA) I)|
|Background||This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus altering the topology of DNA. This gene is localized to chromosome 20 and has pseudogenes which reside on chromosomes 1 and 22. [provided by RefSeq]|
|Synonyms||TOP1 Antibody , topoisomerase (DNA) I Antibody , TOPI Antibody|
|Cellular Localization||Nucleus , nucleolus , nucleoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human Topo I. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Drosophila, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Drosophila (81%), Chicken (96%), Rhesus Monkey (100%), Bovine (100%)|