|Full Name||topoisomerase (DNA) III beta|
|Product Description||Rabbit polyclonal antibody to TOP3B (topoisomerase (DNA) III beta)|
|Background||This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity; however, not all variants have been fully described. [provided by RefSeq]|
|Synonyms||FLJ39376 antibody, TOP3B antibody, topoisomerase III beta antibody, DNA topoisomerase 3-beta-1 antibody, DNA topoisomerase III beta-1 antibody, topoisomerase (DNA) III beta antibody|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human TOP3B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (94%), Rat (94%), Xenopus laevis (87%), Chicken (88%), Rhesus Monkey (99%), Bovine (94%)|