|Full Name||topoisomerase (DNA) II alpha 170kDa|
|Product Description||Rabbit polyclonal antibody to Topoisomerase II alpha (topoisomerase (DNA) II alpha 170kDa)|
|Background||This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq]|
|Synonyms||TOP2 antibody, TP2A antibody, TOP2A antibody, DNA topoisomerase 2-alpha antibody, DNA gyrase antibody, "DNA topoisomerase II, 170 kD antibody", DNA topoisomerase (ATP-hydrolyzing) antibody, "DNA topoisomerase II, alpha isozyme antibody", topoisomerase (DNA) II alpha 170kDa antibody|
|Cellular Localization||Cytoplasm , Nucleus , nucleoplasm |
|Target||Topoisomerase II alpha |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human Topoisomerase II alpha. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Pig (100%)|