|Full Name||topoisomerase (DNA) II beta 180kDa|
|Product Description||Rabbit Polyclonal antibody to Topoisomerase II beta (topoisomerase (DNA) II beta 180kDa)|
|Background||This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq]|
|Synonyms||TOPIIB antibody, top2beta antibody, TOP2B antibody, topoisomerase IIb antibody, DNA topoisomerase 2-beta antibody, DNA topoisomerase II beta antibody, U937 associated antigen antibody, topo II beta antibody, DNA topoisomerase II, 180 kD antibody, antigen MLAA-44 antibody, DNA topoisomerase II, beta isozyme antibody, topoisomerase II beta antibody, topoisomerase (DNA) II beta 180kDa antibody|
|Cellular Localization||Cytoplasm , Nucleus , nucleolus |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human Topoisomerase II beta. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Pig, Rhesus Monkey|
|Predict Reactivity Note||Mouse (89%), Pig (88%), Rhesus Monkey (97%)|