|Product Description||Rabbit Polyclonal antibody to Transthyretin (transthyretin)|
|Background||This gene encodes transthyretin, one of the three prealbumins including alpha-1-antitrypsin, transthyretin and orosomucoid. Transthyretin is a carrier protein; it transports thyroid hormones in the plasma and cerebrospinal fluid, and also transports retinol (vitamin A) in the plasma. The protein consists of a tetramer of identical subunits. More than 80 different mutations in this gene have been reported; most mutations are related to amyloid deposition, affecting predominantly peripheral nerve and/or the heart, and a small portion of the gene mutations is non-amyloidogenic. The diseases caused by mutations include amyloidotic polyneuropathy, euthyroid hyperthyroxinaemia, amyloidotic vitreous opacities, cardiomyopathy, oculoleptomeningeal amyloidosis, meningocerebrovascular amyloidosis, carpal tunnel syndrome, etc. [provided by RefSeq]|
|Synonyms||HsT2651 antibody, PALB antibody, TBPA antibody, TTR antibody, "prealbumin, amyloidosis type I antibody", ATTR antibody, transthyretin antibody, carpal tunnel syndrome 1 antibody, thyroxine-binding prealbumin antibody|
|Cellular Localization||Secreted , Cytoplasm |
|Immunogen||Full length human Transthyretin Recombinant protein.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Pig, Sheep, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (82%), Pig (87%), Sheep (85%), Rhesus Monkey (93%), Chimpanzee (97%), Bovine (85%)|