|Full Name||neurotrophic tyrosine kinase, receptor, type 3|
|Product Description||Rabbit Polyclonal antibody to TrkC (neurotrophic tyrosine kinase, receptor, type 3)|
|Background||This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation and may play a role in the development of proprioceptive neurons that sense body position. Mutations in this gene have been associated with medulloblastomas, secretory breast carcinomas and other cancers. [provided by RefSeq]|
|Synonyms||neurotrophic tyrosine kinase, receptor, type 3 Antibody , gp145(trkC) Antibody , TRKC Antibody , NTRK3 Antibody|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TrkC. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (97%), Rat (97%), Pig (98%), Chicken (82%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (98%)|