|Full Name||tropomyosin 1 (alpha)|
|Product Description||Rabbit Polyclonal antibody to Tropomyosin 1 (tropomyosin 1 (alpha))|
|Background||This gene is a member of the tropomyosin family of highly conserved, widely distributed actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosin is composed of two alpha-helical chains arranged as a coiled-coil. It is polymerized end to end along the two grooves of actin filaments and provides stability to the filaments. The encoded protein is one type of alpha helical chain that forms the predominant tropomyosin of striated muscle, where it also functions in association with the troponin complex to regulate the calcium-dependent interaction of actin and myosin during muscle contraction. In smooth muscle and non-muscle cells, alternatively spliced transcript variants encoding a range of isoforms have been described. Mutations in this gene are associated with type 3 familial hypertrophic cardiomyopathy. [provided by RefSeq]|
|Synonyms||C15orf13 antibody, CMD1Y antibody, CMH3 antibody, HTM-alpha antibody, TMSA antibody, TPM1 antibody, tropomyosin 1 (alpha) isoform 3 antibody, sarcomeric tropomyosin kappa antibody, tropomyosin 1 (alpha) isoform 7 antibody, tropomyosin 1 (alpha) isoform 2 antibody, tropomyosin 1 (alpha) isoform 4 antibody, tropomyosin alpha-1 chain antibody, alpha tropomyosin antibody, tropomyosin 1 (alpha) isoform 5 antibody, cardiomyopathy, hypertrophic 3 antibody, tropomyosin 1 (alpha) isoform 1 antibody, alpha-tropomyosin antibody, tropomyosin-1 antibody, tropomyosin 1 (alpha) isoform 6 antibody, tropomyosin 1 (alpha) antibody|
|Cellular Localization||Cytoplasm , cytoskeleton |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Tropomyosin 1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Pig, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Xenopus laevis, Rabbit, Chicken, Sheep, Bovine|
|Predict Reactivity Note||Zebrafish (80%), Xenopus laevis (83%), Rabbit (88%), Chicken (82%), Sheep (88%), Bovine (88%)|