|Full Name||troponin I type 1 (skeletal, slow)|
|Product Description||Rabbit Polyclonal antibody to TNNI1 (troponin I type 1 (skeletal, slow))|
|Background||Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq]|
|Synonyms||DKFZp451O223 antibody, SSTNI antibody, TNN1 antibody, TNNI1 antibody, "troponin I, slow skeletal muscle antibody", "troponin I, slow-twitch isoform antibody", "troponin I type 1 (skeletal, slow) antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TNNI1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (97%), Pig (98%), Rhesus Monkey (100%), Bovine (97%)|