|Full Name||transient receptor potential cation channel, subfamily M, member 8|
|Product Description||Rabbit polyclonal antibody to TRPM8 (transient receptor potential cation channel, subfamily M, member 8)|
|Background||Receptor-activated non-selective cation channel involved in detection of sensations such as coolness, by being activated by cold temperature below 25 degrees Celsius. Activated by icilin, eucalyptol, menthol, cold and modulation of intracellular pH. Involved in menthol sensation. Permeable for monovalent cations sodium, potassium, and cesium and divalent cation calcium. Temperature sensing is tightly linked to voltage-dependent gating. Activated upon depolarization, changes in temperature resulting in graded shifts of its voltage-dependent activation curves. The chemical agonists menthol functions as a gating modifier, shifting activation curves towards physiological membrane potentials. Temperature sensitivity arises from a tenfold difference in the activation energies associated with voltage-dependent opening and closing.|
|Synonyms||LTRPC6 antibody, MGC2849 antibody, TRPP8 antibody, TRPM8 antibody, LTrpC-6 antibody, long transient receptor potential channel 6 antibody, trp-p8 antibody, short form of the TRPM8 cationic channel antibody, transient receptor potential cation channel subfamily M member 8 antibody, transient receptor potential p8 antibody, transient receptor potential subfamily M member 8 antibody, "transient receptor potential cation channel, subfamily M, member 8 antibody"|
|Cellular Localization||Membrane; Multi-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Trp-p8. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Bovine, Guinea pig|
|Predict Reactivity Note||Mouse (90%), Rat (89%), Dog (95%), Bovine (95%), Guinea pig (91%)|