|Full Name||thioredoxin reductase 1|
|Product Description||Rabbit Polyclonal antibody to TrxR1 (thioredoxin reductase 1)|
|Background||This gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue which is required for catalytic activity. The selenocysteine is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenocysteine-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in several transcript variants encoding the same or different isoforms. [provided by RefSeq]|
|Synonyms||GRIM-12 antibody, MGC9145 antibody, TR antibody, TR1 antibody, TRXR1 antibody, TXNR antibody, TXNRD1 antibody, "thioredoxin reductase 1, cytoplasmic antibody", KM-102-derived reductase-like factor antibody, thioredoxin reductase GRIM-12 antibody, gene associated with retinoic and interferon-induced mortality 12 protein antibody, oxidoreductase antibody, gene associated with retinoic and IFN-induced mortality 12 protein antibody, thioredoxin reductase TR1 antibody, thioredoxin reductase 1 antibody|
|Cellular Localization||Cytoplasm , Isoform 4: Cytoplasm , Nucleus , Isoform 5: Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TrxR1. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Dog, Pig, Rabbit, Chicken, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Dog (95%), Pig (92%), Rabbit (94%), Chicken (85%), Rhesus Monkey (98%), Chimpanzee (99%), Bovine (92%)|