Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||51 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLa , HepG2 , Molt-4 , Raji|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||tryptophan hydroxylase 1|
|Product Description||Rabbit polyclonal antibody to TPH1|
|Background||This gene encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others.|
|Synonyms||MGC119994 antibody, TPRH antibody, TRPH antibody, TPH1 antibody, tryptophan hydroxylase (tryptophan 5-monooxygenase) antibody, tryptophan 5-monooxygenase 1 antibody, tryptophan 5-hydroxylase 1 antibody, L-tryptophan hydroxylase antibody, indoleacetic acid-5-hydroxylase antibody, tryptophan hydroxylase 1 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human TPH1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Chicken, Dog, Mouse, Rabbit, Rat, Xenopus laevis|
|Predict Reactivity Note||Mouse (96%), Rat (96%), Japanese medaka (89%), Xenopus laevis (90%), Dog (99%), Rabbit (98%), Chicken (93%)|