|Full Name||ubiquitin-like modifier activating enzyme 3|
|Product Description||Rabbit Polyclonal antibody to UBA3 (ubiquitin-like modifier activating enzyme 3)|
|Background||The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme associates with AppBp1, an amyloid beta precursor protein binding protein, to form a heterodimer, and then the enzyme complex activates NEDD8, a ubiquitin-like protein, which regulates cell division, signaling and embryogenesis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||DKFZp566J164 antibody, MGC22384 antibody, UBE1C antibody, hUBA3 antibody, UBA3 antibody, ubiquitin-activating enzyme E1C (homologous to yeast UBA3) antibody, ubiquitin-activating enzyme 3 antibody, ubiquitin-like modifier-activating enzyme 3 antibody, Nedd8-activating enzyme hUba3 antibody, "ubiquitin-activating enzyme E1C (UBA3 homolog, yeast) antibody", NEDD8-activating enzyme E1 catalytic subunit antibody, "UBA3, ubiquitin-activating enzyme E1 homolog antibody", NEDD8-activating enzyme E1C antibody, ubiquitin-like modifier activating enzyme 3 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human UBA3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Zebrafish (85%), Xenopus laevis (84%), Rhesus Monkey (100%), Bovine (98%)|