| Full Name | uncoupling protein 1 (mitochondrial, proton carrier) |
| Background | Mitochondrial uncoupling proteins (UCP) are members of the family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed only in brown adipose tissue, a specialized tissue which functions to produce heat. [provided by RefSeq] |
| Synonyms | uncoupling protein 1 (mitochondrial, proton carrier) Antibody , SLC25A7 Antibody , UCP Antibody |
| Cellular Localization | Mitochondrion inner membrane; Multi-pass membrane protein |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | GT635 |
| Isotype | IgG2b |
| Immunogen | Carrier-protein conjugated synthetic peptide encompassing a sequence within the N-terminus region of human UCP1. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Mouse, Pig |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Human, Rat |
| Predict Reactivity Note | Human (100%), Rat (100%) |
| Conjugation | Unconjugated |