|Full Name||uncoupling protein 1 (mitochondrial, proton carrier)|
|Product Description||Rabbit polyclonal to UCP1|
|Background||Mitochondrial oxidative phosphorylation makes possible ATP synthesis using the energy available from substrate oxidation at the respiratory chain. These processes are coupled through the proton electrochemical potential gradient generated during the transfer of electrons from the substrate to oxygen. The uncoupling proteins (UCPs) are mitochondrial inner membrane proteins that are considered to be transporters functioning as enzymatic uncouplers of oxidative phosphorylation. They are capable of returning protons pumped by the respiratory chain to the mitochondrial matrix. Uncoupling proteins currently comprise UCP1, UCP2, UCP3, UCP4, and UCP5. UCP1 is a 32 kDa protein that is active as a proton channelforming dimer. It can bind purine nucleotides and is capable of being stimulated by fatty acids. Proton transport by UCP1 has been shown to depend on CoQ (ubiquinone) as an obligatory cofactor. UCP1 is exclusively expressed in BAT in rodents and in neonates where it is regulated by norepinephrine and thyroid hormones. Stimulated BAT is able to dissipate energy as heat via uncoupled mitochondrial respiration. The liberated heat can serve several physiological functions, e.g. for body heating during emergence from hibernation or during cold exposure, for burning body fat and consequently for body weight regulation.|
|Synonyms||P25874, UCP1, UCP, 113730, 7350, SLC25A7|
|Cellular Localization||Integral membrane protein. Mitochondrial inner membrane. |
|Specificity||The antibody does not cross-react with UCP2 or UCP3.|
|Immunogen||Synthetic peptide conjugated to KLH, corresponding to amino acids 145-159 of Human UCP1, with N-terminal cysteine added.|
|Species Reactivity||Human, Mouse, Rat, Cat, Ferret|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Bovine, Dog, Monkey, Rabbit, Sheep|
|Predict Reactivity Note||Bovine (93%), Dog (93%), Monkey (100%), Rabbit (93%), Sheep (93%)|