|Full Name||uncoupling protein 2 (mitochondrial, proton carrier)|
|Product Description||Rabbit Polyclonal antibody to UCP2 (uncoupling protein 2 (mitochondrial, proton carrier))|
|Background||Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq]|
|Synonyms||BMIQ4 Antibody , uncoupling protein 2 (mitochondrial, proton carrier) Antibody , UCPH Antibody , SLC25A8 Antibody|
|Cellular Localization||Mitochondrion inner membrane; Multi-pass membrane protein |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human UCP2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Sheep, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Dog (100%), Sheep (100%), Rhesus Monkey (100%), Bovine (100%)|