|Full Name||uncoupling protein 3 (mitochondrial, proton carrier)|
|Product Description||Rabbit Polyclonal antibody to UCP3 (uncoupling protein 3 (mitochondrial, proton carrier))|
|Background||Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. The different UCPs have tissue-specific expression; this gene is primarily expressed in skeletal muscle. This gene's protein product is postulated to protect mitochondria against lipid-induced oxidative stress. Expression levels of this gene increase when fatty acid supplies to mitochondria exceed their oxidation capacity and the protein enables the export of fatty acids from mitochondria. UCPs contain the three solcar protein domains typically found in MACPs. Two splice variants have been found for this gene.|
|Synonyms||SLC25A9 antibody, UCP3 antibody, solute carrier family 25 member 9 antibody, Uncoupling protein-3 antibody, mitochondrial uncoupling protein 3 antibody, UCP 3 antibody, uncoupling protein 3 (mitochondrial, proton carrier) antibody|
|Cellular Localization||Mitochondrion inner membrane; Multi-pass membrane protein |
|Immunogen||Full length human UCP3 Recombinant protein.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Dog, Pig, Sheep, Bovine|
|Predict Reactivity Note||Mouse (85%), Dog (91%), Pig (90%), Sheep (87%), Bovine (87%)|