Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||61 kDa (note)
|Positive Controls||293T , A431 , HeLa , HepG2 , H1299 , mouse liver|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||UDP glucuronosyltransferase 1 family, polypeptide A6|
|Product Description||Rabbit Polyclonal antibody to UGT1A6 (UDP glucuronosyltransferase 1 family, polypeptide A6)|
|Background||This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq]|
|Synonyms||GNT1 antibody, HLUGP antibody, HLUGP1 antibody, MGC29860 antibody, UDPGT antibody, UDPGT 1-6 antibody, UGT1 antibody, UGT1A6S antibody, UGT1F antibody, UGT1A6 antibody, UGT1.6 antibody, UDP-glucuronosyltransferase 1-F antibody, UDP-glucuronosyltransferase 1-6 antibody, phenol-metabolizing UDP-glucuronosyltransferase antibody, UDP-glucuronosyltransferase 1 family polypeptide A6s antibody, UGT1*6 antibody, UDP glycosyltransferase 1 family, polypeptide A6 antibody, UDP-glucuronosyltransferase 1A6 antibody, UGT-1F antibody, UGT1-06 antibody, UDP glucuronosyltransferase 1 family, polypeptide A6 antibody|
|Cellular Localization||Microsome , Endoplasmic reticulum membrane; Single-pass membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human UGT1A6. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|