|Full Name||unc-13 homolog B (C. elegans)|
|Product Description||Rabbit Polyclonal antibody to UNC13B (unc-13 homolog B (C. elegans))|
|Background||This gene is expressed in the kidney cortical epithelial cells and is upregulated by hyperglycemia. The encoded protein shares a high level of similarity to the rat homolog, and contains 3 C2 domains and a diacylglycerol-binding C1 domain. Hyperglycemia increases the levels of diacylglycerol, which has been shown to induce apoptosis in cells transfected with this gene and thus contribute to the renal cell complications of hyperglycemia. Studies in other species also indicate a role for this protein in the priming step of synaptic vesicle exocytosis. [provided by RefSeq]|
|Synonyms||MGC133279 antibody, MGC133280 antibody, MUNC13 antibody, UNC13 antibody, Unc13h2 antibody, hmunc13 antibody, UNC13B antibody, homolog of rat Munc13 (diacylglycerol-binding) antibody, munc13-2 antibody, protein unc-13 homolog B antibody, unc-13 homolog B (C. elegans) antibody|
|Cellular Localization||Cytoplasm (By similarity) , Membrane; Peripheral membrane protein (By similarity) , Cell membrane (By similarity) , Cell junction , synapse (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human UNC13B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (98%), Bovine (99%)|