|Full Name||ubiquitin specific peptidase 33|
|Product Description||Rabbit Polyclonal antibody to USP33 (ubiquitin specific peptidase 33)|
|Background||Deubiquitinating enzyme involved in various processes such as cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'-and 'Lys-63'-linked polyubiquitin chains.|
|Synonyms||KIAA1097 antibody, MGC16868 antibody, VDU1 antibody, USP33 antibody, ubiquitin thioesterase 33 antibody, hVDU1 antibody, pVHL-interacting deubiquitinating enzyme 1 antibody, ubiquitin-specific-processing protease 33 antibody, deubiquitinating enzyme 33 antibody, ubiquitin specific protease 33 antibody, ubiquitin carboxyl-terminal hydrolase 33 antibody, ubiquitin thiolesterase 33 antibody, VHL-interacting deubiquitinating enzyme 1 antibody, ubiquitin specific peptidase 33 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human USP33. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Bovine|
|Predict Reactivity Note||Mouse (98%), Rat (98%), Zebrafish (83%), Bovine (99%)|