USP5 antibody [C1C3]
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||96 kDa (note)
|Positive Controls||293T , A431 , H1299 , HeLaS3 , HepG2 , Molt-4 , Raji , mouse brain|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||ubiquitin specific peptidase 5 (isopeptidase T)|
|Product Description||Rabbit Polyclonal antibody to USP5 (ubiquitin specific peptidase 5 (isopeptidase T))|
|Background||Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM]|
|Synonyms||ISOT antibody, USP5 antibody, isopeptidase T antibody, ubiquitin thiolesterase 5 antibody, deubiquitinating enzyme 5 antibody, ubiquitin isopeptidase T antibody, ubiquitin specific protease 5 (isopeptidase T) antibody, ubiquitin-specific-processing protease 5 antibody, ubiquitin-specific protease-5 (ubiquitin isopeptidase T) antibody, ubiquitin thioesterase 5 antibody, ubiquitin carboxyl-terminal hydrolase 5 antibody, ubiquitin specific peptidase 5 (isopeptidase T) antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human USP5. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (99%), Xenopus laevis (82%), Rhesus Monkey (92%), Bovine (99%)|