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1 .GTX19247 Ubiquitin antibody

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Ubiquitin antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsIHC, IP, WB
  • Species reactivityHuman, Mouse
  • Publication  ( 2 )
Cat No: GTX19247
Package Price Qty
100 μlUSD 319.00
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  • Anti-Ubiquitin antibody used in Western Blot (WB). GTX19247
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    Reference (2)
  • Application Information: Ubiquitin antibody

Catalog Number GTX19247
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( 0 )
Publication ( 2 )
Product Name Ubiquitin antibody
See all Ubiquitin products
ApplicationsIHC, IP, WB
Application NoteFor IHC: Use at a dilution of 1:150 - 1:250. For IP: Use at a dilution of 1:50 - 1:150. For WB: Use at a dilution of 1:800 - 1:1,200. Optimal dilutions/concentrations should be determined by the researcher.
Form SuppliedLiquid
Concentrationwhole antiserum
PurificationUnpurified

  • Specifications: Ubiquitin antibody

Full Nameubiquitin B
BackgroundUbiquitin is a highly conserved protein of about 8.5 kDa molecular weight, which has an ATP dependent role in the targeting of proteins for proteolytic degradation. To perform this function, the protein to be degraded is first covalently attached to the C terminus of ubiquitin, and the ubiquitinated complex is then recognized by a complex of degradative enzymes. Interestingly, ubiquitin also becomes covalently bonded to many types of pathological inclusions, which appear to be resistant to normal degradation. Therefore, ubiquitin antibodies are very useful for studies of these inclusions. For example, the neurofibrillary tangles and paired helical filaments diagnostic of Alzheimer's disease, Lewy bodies seen in Parkinson's disease, and Pick bodies found in Pick's disease are all heavily ubiquitinated and can be readily visualized with ubiquitin antibodies.
SynonymsUBB Antibody
Cellular LocalizationCytoplasmic and Nuclear
SpecificityGTX19247 can identify free ubiquitin as well as ubiquinated proteins.
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenFull length native protein: Ubiquitin purified from bovine red blood cells.
Antigen SpeciesBovine
Species ReactivityHuman, Mouse
ConjugationUnconjugated

  • Storage Conditions: Ubiquitin antibody

Storage BufferWhole serum
Storage InstructionKeep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Ubiquitin antibody validated data
  • Anti-Ubiquitin antibody used in Western Blot (WB). GTX19247
    • GTX19247 WB Image
      WB analysis on heat shocked Hela cell lysate
      Top
  • Anti-Ubiquitin antibody used in Western Blot (WB). GTX19247
    • GTX19247 WB Image
      WB analysis on heat shocked Hela cell lysate
      Top
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  • Reference for Ubiquitin antibody
Application References Application Reactivity
Tung YT et al. Mir-17?92 Governs Motor Neuron Subtype Survival by Mediating Nuclear PTEN. Cell Rep 11 (8):1305-18 (2015). WB Human
Hsu HY et al. Fucoidan induces changes in the epithelial to mesenchymal transition and decreases metastasis by enhancing ubiquitin-dependent TGFβ receptor degradation in breast cancer. Carcinogenesis 34 (4):874-84 (2013).
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All products are for research use only—Not for use in diagnostic procedures.