|Full Name||ATPase, H+ transporting, lysosomal V0 subunit a4|
|Product Description||Rabbit polyclonal antibody to V-ATPase 116 kDa isoform a4 (ATPase, H+ transporting, lysosomal V0 subunit a4)|
|Background||This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing. [provided by RefSeq]|
|Synonyms||A4 antibody, ATP6N1B antibody, ATP6N2 antibody, MGC130016 antibody, MGC130017 antibody, RDRTA2 antibody, RTA1C antibody, RTADR antibody, STV1 antibody, VPH1 antibody, VPP2 antibody, ATP6V0A4 antibody, "vacuolar proton pump, subunit 2 antibody", V-ATPase 116 kDa antibody, "H(+)-transporting two-sector ATPase, noncatalytic accessory protein 1B antibody", "ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 1B antibody", "ATPase, H+ transporting, lysosomal (vacuolar proton pump) non-catalytic accessory protein 2 (38kD) antibody", V-type proton ATPase 116 kDa subunit a isoform 4 antibody, vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform antibody, V-type proton ATPase 116 kDa subunit a antibody, vacuolar proton pump 116 kDa accessory subunit antibody, "ATPase, H+ transporting, lysosomal V0 subunit a4 antibody"|
|Cellular Localization||Apical cell membrane; Multi-pass membrane protein |
|Target||V-ATPase 116 kDa isoform a4|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human V-ATPase 116 kDa isoform a4. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (87%), Bovine (82%)|